Figure 1 | Scientific Reports

Figure 1

From: Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling

Figure 1

NGR1 attenuated neointima formation in a murine femoral artery wire injury model. Eight week-old C57BL/6 J male mice were intraperitoneally injected with NGR1 (10 mg/kg/d) or saline (Con) daily for three weeks. (A) H&E staining and (B) elastic van Gieson (EVG) staining of non-injured right (Sham) and injured left femoral arteries. Scale bar, 50 μm. (C) Morphometric analysis of neointima area, intima-to-media ratio, lumen, and vessel area of injured femoral arteries from mice injected with vehicle or NGR1. (D) Representative immunofluorescence stained images of the sections from sham and wire-injured femoral arteries. Scale bar, 50 μm. (E) Percentage of BrdU positive cell number was quantified in sections from sham operated and injured femoral arteries from vehicle or NGR1 treated mice. Data shown are means ± SEM. N = 4 for control and N = 5 for NGR1 treatment. *P < 0.05; compared with control group. Three independent experiments were performed.

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