Figure 7
From: Lantibiotic production is a burden for the producing staphylococci
Overview on Gdm and Epis mode of action on the producers. Gallidermin/Epidermin are expressed in an inactive pro-form and secreted by the ABC-tranporter GdmHT/EpiHT, the secreted pro-form is processed by specific protease GdmP/EpiP to active Gdm/Epi. Despite the immunity system Gdm/Epi can inhibit the growth of the producer strain causing enhanced excretion of cytoplasmic proteins and the release of ATP and lipids.
