Figure 6
Whole cell computational models using hKv9.2 reflect changes in electrophysiological behavior. (A) Representative example of 5 seconds of spontaneous activity in flies expressing only native Shab (left panel), native Shab with hKv9.2 (middle panel), or native Shab with hKv9.2-D379E (right panel). (B) Model description of 5 seconds of neuronal activity using only native Shab (left panel), native Shab with hKv9.2 (middle panel), or native Shab with hKv9.2-D379E (right panel) at ZT0 (where ZT0 is lights-on/dawn and ZT12 is lights-off/dusk). (C) The model description of the spontaneous firing rate of action potentials in flies expressing either hKv9.2 subunit is not significantly different to the experimental data.
