Table 1 Demographic characteristics of cohort participants.

From: Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study

 

NAL−

NAL+

p

Gender (M/F)

19/46

13/22

0.419

Age (years, mean ± SD)

77.61 ± 5.55

79.22 ± 5.38

0.165

BMI (mean ± SD)

27.38 ± 4.47

28.05 ± 4.73

0.486

nAPOE ε4 carriers (%)

5 (7.7)

16 (45.7)

<0.0001

MMSE (mean ± SD)

28.50 ± 1.16

28.80 ± 1.10

0.225

MoCA (mean ± SD)

27.43 ± 1.67

27.03 ± 1.92

0.278

Education (years, mean ± SD)

14.84 ± 3.37

13.64 ± 2.91

0.078

Testosterone (nmol/L, mean ± SD), males

14.43 ± 6.16

11.66 ± 3.77

0.160

Testosterone (nmol/L, mean ± SD), females

1.45 ± 2.55

1.26 ± 0.81

0.738

Oestradiol (pmol/L, mean ± SD), males

113.16 ± 47.83

117.23 ± 35.17

0.795

Oestradiol (pmol/L, mean ± SD), females

91.22 ± 118.71

73.90 ± 28.97

0.523

FBB-PET SUVR (mean ± SD, n = 100)

1.15 ± 0.08

1.71 ± 0.26

—

HV% (left; right lobes, mean ± SD, n = 96)

0.195 ± 0.020; 0.199 ± 0.021

0.194 ± 0.019; 0.199 ± 0.018

0.805; 0.890

  1. Baseline characteristics including gender, age, body mass index (BMI), APOE ε4 status, mini mental state examination (MMSE) scores, Montreal Cognitive Assessment (MoCA, adjusted for education) scores, years of education, sex hormone levels, neocortical amyloid load (NAL) represented by the standard uptake value ratio (SUVR) of ligand 18F-Florbetaben (FBB) in the neocortical region normalised with that in the cerebellum, and hippocampal volume (HV) normalised by the intracranial volume, have been compared between NAL− (SUVR <1.35) and NAL+ (SUVR ≥1.35) study participants. Chi-square test or linear models were employed as appropriate. Ninety-six participants underwent MRI (nNAL− = 64, nNAL+ = 32).
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