Figure 1 | Scientific Reports

Figure 1

From: Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma

Figure 1

Downregulation of C14MC in gliomas. (a) Downregulation of C14MC in gliomas (TLDA data). X-axis shows the group of samples; Grade II (Diffuse astrocytoma; n = 15), Grade III (Anaplastic astrocytoma; n = 9), Grade IV (Glioblastoma; n = 35) and controls (n = 10). Y-axis represents relative expression (delta Ct values). Median expression value of each sample group is represented in the box-plot. (b) (A) Downregulation of C14MC in gliomas (TCGA small RNA sequencing data). X-axis shows the group of samples; Grade II (Diffuse astrocytoma; n = 46), Grade III (Anaplastic astrocytoma; n = 97) and controls (n = 5). Y-axis represents relative expression (log transformed). Median expression value of each sample group is represented in the box-plot. (B) Downregulation of C14MC in gliomas (TCGA microarray data). X-axis shows the group of samples; Grade IV (Glioblastoma; n = 505) and controls (n = 10). Y-axis represents relative expression (lowess normalised). Median expression value of each sample group is represented in the box-plot. (c) Moderate association of C14MC expression with survival of GBM patients. X-axis represents meta-expression, derived from principal component 1 (extracted from Z-score values of Fold change for each miR across all GBM samples). Y-axis shows survival in days. The association was tested using Pearson’s test, after removing one outlier sample.

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