Figure 3 | Scientific Reports

Figure 3

From: Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma

Figure 3

Target validation of miR-134 and miR-485-5p. Panel A: Histogram showing luciferase reporter based miR-mRNA interaction of miR-134 with EGFR and RAF1. Panel B: Histogram showing luciferase reporter based miR-mRNA interaction of miR-485-5p with TP53, and negligible evidence of CDK6 interaction. X-axis represents the conditions (MES: miR mimic + empty vector + scrambled; MTS: miR mimic + target gene UTR + scrambled; MTI: miR mimic + target gene UTR + miR inhibitor), Y-axis shows Firefly/Renilla ratio. Error bars indicate standard error.

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