Figure 1

Plasma and myocardial levels of galectin-3 in the mouse models of cardiomyopathy and ischemia-reperfusion (I/R). Changes in plasma concentrations of Gal-3 and cardiac expression of Gal-3 at mRNA and protein levels in Mst1-TG and non-TG (nTG) mice at 3 and 6 months of age (n = 6∼8/group, A) in β₂-TG (n = 5∼9/group) and nTG mice (n = 4∼6/group) at 3, 6 and 9 months of age (B) and in mice subjected to 1-hour ischemia followed by reperfusion of 24 or 48 hours (n = 5∼7/group) or sham-operation as control (SH, n = 5, C). In hearts from mice subjected to I/R (1/48 h, n = 5) or SH (n = 4), the infarct zone (IZ) was separated from the non-infarct zone (NIZ) and the assays were performed separately. Mean ± SEM. *P < 0.05 vs. nTG or SH, and ^†P < 0.05 vs. 3-month-old β₂-TG or NIZ.