Table 2 Baseline characteristics of the StenoCardia cohort, which served as application cohort for the adjustment model development based on the DETECT cohort.

From: Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain

n

All patients

non-AMI

AMI

p-values

1818

1405

413

Male sex (%)

1208/1818 (66%)

894/1405 (64%)

314/413 (76%)

<0.001

Age, y, mean (SD)

61.4 (13.5)

60.7 (13.9)

64 (11.8)

<0.001

Hypertension

1339/1818 (74%)

1026/1405 (73%)

313/413 (76%)

0.291

Dyslipidemia

1328/1818 (73%)

1017/1405 (72%)

311/413 (75%)

0.266

Diabetes mellitus

344/1816 (19%)

250/1404 (18%)

94/412 (23%)

0.027

Obesity (BMI ≥ 30)

469/1694 (28%)

360/1305 (28%)

109/389 (28%)

0.918

Smoking

454/1814 (25%)

305/1402 (22%)

149/412 (36%)

<0.001

Former Smoking

582/1740 (33%)

444/1352 (33%)

138/388 (36%)

0.346

Family history of MI

632/1814 (35%)

496/1402 (35%)

136/412 (33%)

0.408

History of MI

434/1813 (24%)

334/1401 (24%)

100/412 (24%)

0.909

Known CAD

679/1816 (37%)

533/1403 (38%)

146/413 (35%)

0.359

CRP, mg/L, median (IQR)

2.5 (1.3, 5.8)

2.3 (1.1, 5.1)

3.4 (1.7, 8.8)

<0.001

eGFR, mL/min/1.73 m2, median (IQR)

79 (21.4)

80 (21)

75.5 (22.3)

<0.001

Troponin I, ng/mL, median (IQR)

0 (0, 0.1)

0 (0, 0)

0.6 (0.1, 3.5)

<0.001

Total Cholesterol, mg/dL, mean (SD)

199.2 (49.1)

197.6 (48.7)

205 (50.1)

0.013

LDL Cholesterol, mg/dL, mean (SD)

119.9 (41.9)

117.2 (41)

129.6 (43.8)

<0.001

HDL Cholesterol, mg/dL, mean (SD)

50.5 (15.3)

51.4 (15.6)

47.6 (3.8)

<0.001

  1. Values are n (%) unless otherwise stated. The patients have been grouped by disease status. The parameters are given as proportions, mean (SD), or median (IQR = interquartile range) as appropriate. The p-values for comparison of non-AMI and AMI patients stem from chi-squared tests, two-sided t-tests, and two-sided Wilcoxon tests.
  2. Abbreviations: AMI = acute myocardial infarction; BMI = body mass index; CAD = coronary artery disease; eGFR = estimated glomerular filtration rate; CRP = C-reactive protein; Hb = hemoglobin; MI = myocardial infarction; LDL = low-density lipoprotein; HDL = high-density lipoprotein.