Figure 5 | Scientific Reports

Figure 5

From: Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex

Figure 5

Cohesin loader MAU-2 affects the gene expression during HSN terminal maturation. (A) Fluorescent intensity of Pabts-1b::gfp in HSNs was analyzed in mau-2(qm160) mutants expressing MAU-2 by the unc-86 promoter. Error bars indicate SEM. n ≥ 32, **p < 0.01. (B) The genetic interaction between eor-1 and mau-2 in Pabts-1b::gfp expression at the adult stage. Error bars indicate SEM (n ≥ 30). (C) Localization of YFP::HTZ-1 and extrachromosomal LacO reporter arrays carrying the abts-1b promoter at the L1-2 larval stages in HSNs of mau-2(qm160) mutants. The extrachromosomal LacO reporter array was visualized by the binding of mTurquoise2::LacI. Arrowhead indicates exclusion of YFP::HTZ-1 from reporter arrays. White scale bar shows 2 µm. (D) Percentage of co-localization of YFP::HTZ-1 and reporter arrays carrying the abts-1b promoter in HSNs at the L1 to L2 larval stage was compared between the wild-type background and mau-2(qm160) mutant background. n ≥ 34, **p < 0.01.

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