Figure 1 | Scientific Reports

Figure 1

From: Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion

Figure 1

R568 anti-secretory effects under basal conditions. Summarized are steady-state Isc changes in response to the sequential serosal additions of R568 (10 µM) and lidocaine (Lido, 1.6 mM)/TTX (2 µM). The R568 anti-secretory effect is present in colons of wild-type mice and mice expressing neuronal CaSR (villinCre/Casrflox/flox or villin mice) but is absent in mice lacking neuronal CaSR (nestinCre/Casrflox/flox or nestin mice). NS, no significance.

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