Figure 3 | Scientific Reports

Figure 3

From: Preclinical evaluation of ribociclib and its synergistic effect in combination with alpelisib in non-keratinizing nasopharyngeal carcinoma

Figure 3

Effect of ribociclib on pRB and G1 cell cycle regulating protein expressions in C666-1 and HK1 cells. Cells were treated with ribociclib in 2 concentrations, one of them near their corresponding IC50, for 24 and 48 hours. Phosphorylation of Rb in all cell lines was significantly reduced by ribociclib but cyclin D1 and cyclin E expressions were upregulated. Cleaved PARP was moderately detected after 48 hours treatment in C666-1 but not in HK1.

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