Table 5 VDR and MEGALIN SNP haplotype (SNPHAP) associations with prevalent metabolic disturbances (V2): multiple logistic regression models, (n = 539); HANDLS study.

From: Vitamin D Metabolism-Related Gene Haplotypes and Their Association with Metabolic Disturbances Among African-American Urban Adults

 

Prevalent metabolic disturbance

All (N = 539)

Men (N = 230)

Women (N = 309)

OR

95%CI

P

OR

95%CI

P

OR

95%CI

P

Obesity: Models A-F

VDR1: GCA (0,1,2)

0.89

(0.68;1.16)

0.37

1.05

(0.68;1.60)

0.83

0.78

(0.55;1.11)

0.17

VDR2: AAG (0,1,2)

1.43

(1.01;2.02)

0.044

1.08

(0.63;1.84)

0.78

1.79

(1.09;2.95)

0.023

VDR3: GAA (0,1,2)

0.96

(0.69;1.36)

0.85

0.94

(0.53;1.66)

0.82

0.99

(0.63;1.56)

0.96

VDR4: AAA(0,1,2)

1.17

(0.72;1.88)

0.53

1.32

(0.62;2.81)

0.47

1.19

(0.61;2.29)

0.61

MEGALIN1: GCC (0,1,2)

1.08

(0.77;1.50)

0.67

0.95

(0.54;1.67)

0.85

1.13

(0.73;1.77)

0.56

MEGALIN2: ACC (0,1,2)

1.06

(0.76;1.46)

0.74

1.17

(0.68;1.99)

0.57

1.05

(0.68;1.62)

0.82

Central obesity: Models A-F

VDR1: GCA (0,1,2)

1.03

(0.76;1.40)

0.83

1.10

(0.72;1.69)

0.65

1.07

(0.66;1.73)

0.79

VDR2: AAG (0,1,2)

1.18

(0.79;1.77)

0.41

0.90

(0.54;1.52)

0.71

1.75

(0.82;3.77)

0.15

VDR3: GAA (0,1,2)

1.02

(0.69;1.52)

0.92

1.22

(0.69;2.14)

0.49

0.84

(0.46;1.56)

0.59

VDR4: AAA(0,1,2)

1.30

(0.73;2.32)

0.37

1.55

(0.71;3.38)

0.27

0.99

(0.41;2.41)

0.98

MEGALIN1: GCC (0,1,2)

1.04

(0.71;1.53)

0.84

0.77

(0.44;1.35)

0.36

1.35

(0.72;2.52)

0.35

MEGALIN2: ACC (0,1,2)

1.10

(0.76;1.62)

0.61

1.26

(0.74;2.15)

0.40

1.05

(0.57;1.94)

0.87

Metabolic syndrome: Models A-F

VDR1: GCA (0,1,2)

0.96

(0.71;1.31)

0.81

1.463

(0.88;2.44)

0.14

0.68

(0.43;1.06)

0.086

VDR2: AAG (0,1,2)

1.25

(0.86;1.83)

0.25

0.87

(0.42;1.80)

0.71

1.60

(0.97;2.63)

0.063

VDR3: GAA (0,1,2)

1.13

(0.75;1.68)

0.56

0.693

(0.32;1.50)

0.35

1.49

(0.89;2.49)

0.13

VDR4: AAA(0,1,2)

0.60

(0.31;1.14)

0.12

0.72

(0.26;1.95)

0.51

0.52

(0.21;1.28)

0.16

MEGALIN1: GCC (0,1,2)

0.75

(0.50;1.11)

0.15

0.70

(0.34;1.44)

0.33

0.72

(0.43;1.21)

0.22

MEGALIN2: ACC (0,1,2)

1.08

(0.74;1.58)

0.68

1.07

(0.55;2.12)

0.83

1.17

(0.71;1.92)

0.54

  1. Abbreviations: BMI = body mass index (calculated as weight in kg/square of height in meters); SNP = Single Nucleotide polymorphism; SNPHAP = SNP haplotype; V2 = Visit 2; VDR = Vitamin D receptor gene; Note that VDR1, VDR2, VDR3 denote VDR SNPHAP, whereas MEGALIN1, MEGALIN2 and MEGALIN3 denote MEGALIN SNPHAP.
  2. 1See Table 1 for more details on definition the SNP haplotypes. (0,1,2) refers to ordinal coding with “0”, “1” and “2” copies of each haplotype. Three VDR SNP were combined to form the haplotypes, namely BsmI, ApaI and TaqI. Only haplotypes 1 and 2 were selected for MEGALIN since their overall prevalence was > 10%.
  3. 2Models were adjusted for age, sex, poverty status, education, current smoking status, current illicit drug use, self-rated health, total energy intake, HEI-2010 total score, 10 principal components for population structure, and the inverse mills ratio.
  4. 3P < 0.05 for null hypothesis that sex × SNPHAP interaction term = 0 in a model where main effect of sex was added.
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