Table 1 AUC values and DRS for different pathogens. Figures in round brackets show the CI 95% (2,000 bootstrap replicates).

From: A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms

 

n

AUC

Sensitivity

Specificity

DRS

P -value

All patients

      

Rotavirus

53

—

—

—

—

 

EAEC

18

68.7 (54.0-83.3)

69.8 (56.6–81.1)

66.7 (44.4–88.9)

−6.76

2.160 × 10–2

EPEC

10

78.6 (66.1–90.9)

60.4 (47.2–73.6)

90.0 (70.0–100.0)

−7.74

8.879 × 10−3

DAEC

21

73.6 (61.7–85.5)

67.9 (54.7–81.1)

76.2 (57.1–90.5)

−7.21

2.494 × 10−3*

Salmonella

36

80.8 (71.9–89.6)

67.9 (54.7–79.2)

83.3 (69.4–94.4)

−7.41

6.927 × 10−7*

Shigella

36

89.0 (82.5–95.6)

69.8 (56.6–83.0)

100.0 (100.0–100.0)

−6.88

3.140 × 10−12*

All Bacteria

121

80.0 (72.6–87.4)

67.9 (54.7–79.2)

84.3 (77.7–90.1)

−7.41

6.944 × 10−11*

Severe & Moderate

Rotavirus

19

—

—

—

—

 

EAEC

6

58.8 (28.4–89.2)

79.0 (57.9–94.7)

33.3 (0.0–66.7)

−6.25

6.102 × 10−1

EPEC

3

84.2 (52.3–100.0)

100.0 (100.0–100.0)

66.7 (0.0–100.0)

−4.37

1.780 × 10−1

DAEC

6

86.0 (66.6–100.0)

89.5 (73.7–100.0)

66.7 (33.3–100.0)

−5.80

4.057 × 10−2

Salmonella

12

83.3 (69.0–97.6)

68.4 (47.4–89.5)

83.3 (58.3–100.0)

−7.41

5.879 × 10−3*

Shigella

22

93.5 (86.6–100.0)

73.7 (52.6–94.7)

100.0 (100.0–100.0)

−6.75

2.219 × 10−7*

All bacteria

49

85.3 (75.7–94.9)

79.0 (57.9–94.7)

77.6 (65.3–87.8)

−6.40

2.126 × 10−6*

Mild

Rotavirus

34

—

—

—

—

—

EAEC

12

73.5 (57.6–89.5)

67.7 (47.1–82.4)

75.0 (0.5–100.0)

−6.76

1.818 × 10−2

EPEC

7

74.8 (59.3–90.3)

67.7 (47.1–82.4)

100.0 (100.0–100.0)

−7.57

4.668 × 10−2

DAEC

15

69.0 (53.9–84.2)

64.7 (47.1–79.4)

80.0 (60.0–100.0)

−7.78

3.601 × 10−2

Salmonella

24

80.0 (68.6–91.4)

67.7 (53.0–82.4)

66.7 (83.3–95.8)

−7.55

4.698 × 10−5*

Shigella

14

84.2 (73.4–95.1)

67.7 (52.9–82.4)

100.0 (100.0–100.0)

−6.88

1.157 × 10−5*

All bacteria

72

77.0 (66.5–87.4)

67.7 (50.0–82.4)

86.1 (77.8–93.1)

−7.57

8.154 × 10−6*

  1. P-values evaluate the significance of the difference between bacterial pathogen vs. viral infection under a t-test; an asterisk. (*) indicates those values surpassing a Bonferroni correction for multiple tests. Note that the reference viral pathogen in our study is rotavirus (for which there is only very little information available in the literature; e.g.43).
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