Figure 5 | Scientific Reports

Figure 5

From: The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells

Figure 5

Down-regulation of the expression of Wnt downstream target genes by RS-PP-050. Quantitative real-time PCR showing the concentration-dependent reduction in mRNA expression of Wnt target genes: (A) c-myc, (B) cyclin D1, (C) survivin, and (D) MMP-7 in HT-29 cells after treatment with RS-PP-050 for 24 h. The relative mRNA expression was quantified and normalized with GAPDH. Data are means ± S.E.M. compared with the vehicle control (n = 3) (*P < 0.05, **P < 0.01).

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