Table 2 IC50 values (µM) for the tested compounds in HT-29 cells at various time points.

From: The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells

Compounds

Time (h)

24

48

72

RS-PP-050

11.43 ± 1.52

3.41 ± 0.82

3.25 ± 0.81

Andrographolide

48.64 ± 3.25

31.79 ± 3.14

25.64 ± 3.03

Vinblastine

5.02 ± 1.02

0.07 ± 0.03

0.05 ± 0.02

Doxorubicin

25.90 ± 0.07

3.29 ± 0.49

1.29 ± 0.79

Ellipticine

13.35 ± 1.11

8.18 ± 1.89

4.66 ± 1.19

  1. IC50 values (µM) of HT-29 cells after treatment with the tested compounds; RS-PP-050, andrographolide, vinblastine, doxorubicin, and ellipticine for 24, 48, and 72 h. Cell viability was assessed with MTT assay. IC50 value is the concentration that inhibits 50% of cell proliferation. Each value represents as mean ± SEM compared to the vehicle control from three independent experiments repeated in triplicates.
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