Table 1 Active ABP-labelled serine proteases secreted from the colonic mucosa of control and IBD patients.

From: Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Protease family

Gene symbol

Protein name

Predicted MW

Activity index

Ctrl

CD

UC

S01

F2

Thrombin−α/−β/−γ

32/28/15

<2

97.57

4.9

CTSG

Cathepsin G

29

<2

n.d.

5.8

KLKB1

Plasma kalikrein

71

4.2

<2

5.1

PLG

Plasmin

91

2.5

<2

2.3

TPSAB1/B2

Tryptase−α/β1/−β2

31/30

2.3

2.03

<2

CELA3A

Chymotrypsin-like elastase family member 3A

30

2.8

<2

<2

M01

RNPEP

Aminopeptidase B

73

<2

<2

19

  1. The list shows the active ABP-labelled proteases identified by LC-MS/MS analysis of pooled supernatant samples from control and IBD patients, showing the respective protease family, gene symbol, protein name, predicted molecular weight and the activity index reflecting the sensitivity of ABP labelling to protease inhibition (−/+AEBSF ratio).
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