Figure 5 | Scientific Reports

Figure 5

From: Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs

Figure 5

Differential expression of piRNAs in liver tissue samples: Differentially expressed piRNAs were quantified and a heatmap was prepared (FDR < 0.05) for each disease stage (Cirrhosis, Low-grade dysplastic nodule, High-grade dysplastic nodule, Early stage Hepatocellular carcinoma and Advanced stage Hepatocellular carcinoma) with healthy control samples (A–E). All enriched piRNAs were summarized by a Venn diagram, which identified 30 piRNAs commonly expressed in all stages and 52 piRs were specifically dysregulated in advanced hepatocellular carcinoma (F). (G) A Circos plot was prepared incorporating all differential expressions of piRNAs in cirrhosis, low-grade dysplastic nodule, high-grade dysplastic nodule, early hepatocellular carcinoma, and hepatocellular carcinoma tissue samples compared with healthy samples (FDR < 0.05). Chromosome and bands were listed in chromosomal positions of piRNAs affected expression in liver disease vs healthy samples. The Innermost ring are cirrhosis, then low-grade dysplastic nodule, high-grade dysplastic nodule, early hepatocellular carcinoma, and hepatocellular carcinoma with darker and lighter background colors representing upregulated and downregulated genes respectively.

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