Figure 6

Differential expression of long non-coding RNAs (lncRNAs) in liver tissue samples: Differential expression of lncRNAs were quantified and a heatmap view was prepared (FDR < 0.05) for each disease stage (Cirrhosis, Low-grade dysplastic nodule, High-grade dysplastic nodule, Early stage Hepatocellular carcinoma, and Advanced stage Hepatocellular carcinoma) with healthy control samples (A–E). All stages of liver disease enriched lncRNAs were summarized by a Venn diagram, which identified 109 lncRNAs commonly expressed in all stages with 39 lncRNAs specifically enriched in early hepatocellular carcinoma and only three lncRNAs enriched in advanced hepatocellular carcinoma (F). (G) A Circos plot was prepared incorporating all differential expressions of lncRNAs in cirrhosis, low-grade dysplastic nodule, high-grade dysplastic nodule, early hepatocellular carcinoma, and hepatocellular carcinoma tissue samples compared with healthy samples (FDR < 0.05). Chromosome and bands were listed in chromosomal positions of lncRNAs affected expression in liver disease vs healthy samples. The Innermost ring represents cirrhosis, then low-grade dysplastic nodule, high-grade dysplastic nodule, early hepatocellular carcinoma and hepatocellular carcinoma with darker and lighter background colors representing upregulated and downregulated genes respectively.