Figure 8 | Scientific Reports

Figure 8

From: Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs

Figure 8

Differential expression of snoRNAs and mitochondrial RNAs (mt-RNAs) liver tissue samples: Differential expression of snoRNAs and mt-RNAs were quantified and a heatmap view was prepared (FDR < 0.05) for each disease stage (Cirrhosis, Low-grade dysplastic nodule, High-grade dysplastic nodule, Early stage Hepatocellular carcinoma and Advanced stage of Hepatocellular carcinoma) with healthy control samples (A–E). All stages of liver disease enriched sno/mt-RNAs were summarized by a Venn diagram, which identified 5 small RNAs commonly expressed in all stages and 1 snoRNA was specifically enriched in advanced hepatocellular carcinoma (F). (G) A Circos plot was prepared incorporating all differential expressions of sno/mt-RNAs in cirrhosis, LGDN, HGDN, eHCC and HCC tissue samples compared with healthy samples (FDR < 0.05). Chromosome and bands were listed in chromosomal positions of sno/mt-RNAs expression in liver disease vs healthy samples. The Innermost ring is cirrhosis, then low-grade dysplastic nodule, high-grade dysplastic nodule, early hepatocellular carcinoma and hepatocellular carcinoma with darker and lighter background colors representing upregulated and downregulated genes respectively.

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