Figure 3

MiR-29c amplified the therapeutic effects of cisplatin in vitro and in vivo. (A,B) miR-29c overexpression and knock down showed opposite effects on cisplatin sensitivity in SPC-A-1 and A549 cells. (C,D) A549 cells expressing miR-29c or a negative control were subcutaneously transplanted in mice. Mice were treated with cisplatin or saline. Tumor volume (C) and tumor weight (D) were measured. (E) Representative photos of tumors in each group. (F) Relative Ki-67 index in each group. Data was obtained from 5 mice in each group. Data was normalized to the lowest Ki-67 rate of mice in group “con+PBS”, which was set as 100%. (G) The expression of miR-29c in mice tumors. Data was normalized to miR-29c expression of mice #1 in group “con+PBS”. “con” represents mimic control; “cis” represents “cisplatin”; “29c” represents “mimic miR-29c”.