Figure 3 | Scientific Reports

Figure 3

From: Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice

Figure 3

Intravenous (i.v.) pharmacokinetics of PMX53 and PMX205 in wild-type mice: Complement C5a receptor 1 antagonists PMX53 (red graph lines) and PMX205 (blue graph lines) concentration vs time profile in plasma (A), brain (B) and spinal cord (C) following single i.v. bolus drug dose of 1 mg/kg of either antagonist in mice at time = 0. Data points represent mean ± SEM of n = 4 mice at each time point.

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