Figure 3
ProNGF expression in lung cancers and normal tissues. (A–F) Immunohistochemical detection of proNGF, representative pictures are shown for normal tissue (A), squamous cell carcinoma (B–D), adenocarcinoma (E) and small cell cancer (F). Scale = 50 μm. (G) ProNGF staining intensities were significantly higher in squamous cell carcinoma and adenocarcinoma than in normal tissues. Corresponding median h-scores are presented in Table 1. The box limits indicate the interquartile range (IQR) with the whiskers extending 1.5 times the IQR from the 25th and 75th percentiles (outliers are represented by dots) (*p < 0.0001 in multiple logistic regression model). (H) ROC curve for proNGF staining intensity level in lung cancers versus normal tissues. The area under the curve was 0.70 (95% CI 0.64 to 0.76).
