Figure 5
Sortilin expression in lung cancers and normal lung tissues. (A–F) Immunohistochemical detection of sortilin, representative pictures are shown for normal tissue (A), squamous cell carcinoma (B–D), adenocarcinoma (E) and small cell cancer (F). Scale = 50 μm. (G) Sortilin staining intensities were significantly higher in adenocarcinoma and small cell cancer. Corresponding median h-scores are presented in Table 1. The box limits indicate the interquartile range (IQR) with the whiskers extending 1.5 times the IQR from the 25th and 75th percentiles (outliers are represented by dots) (*p < 0.0001 in multiple logistic regression model). (H) ROC curve for sortilin staining intensity level in lung cancers versus normal tissues. The area under the curve was 0.46 (95%CI 0.39 to 0.53).
