Figure 6

Nerves in the tumor microenvironment of lung cancer do not express NGF, proNGF, TrkA, p75NTR and sortilin. (A) Immunohistochemical detection of the pan-neuronal marker PGP9.5 was used to detect nerves in lung cancers. The expression of NGF (B), proNGF (C), TrkA (D), p75NTR (E) and sortilin (F) was not detected in serial sections. Black arrows indicate a nerve trunk composed of many axons. Scale = 25 μm.