Table 1 Expression of NGF, proNGF, TrkA, p75NTR and sortilin in lung cancers and association with clinicopathological parameters.

From: The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung

Parameter

NGF Intensity

proNGF Intensity

TrkA Intensity

sortilin Intensity

p75NTR Intensity

Median h-score

IQR

p-value

Median h-score

IQR

p-value

Median h-score

IQR

p-value

Median h-score

IQR

p-value

Median h-score

IQR

p-value

Normal vs cancer

  

<0.0001

  

<0.0001

  

0.002

  

0.43

  

<0.0001

Normal (n = 121)

57

46–70

 

58

47–70

 

18

13–26

 

32

26–41

 

92

81–110

 

Cancer (n = 164)

95

76–112

 

76

58–96

 

13

6–33

 

30

20–48

 

147

116–176

 

Histological Type

  

0.0001

  

0.0001

  

0.0001

  

0.0001

  

0.0001

Squamous (n = 98)

107

85–118

 

73

58–96

 

26

13–57

 

25

18–40

 

132

107–161

 

Adenocarcinoma (n = 58)

84

72–98

 

82

65–98

 

6

4–9

 

40

26–66

 

164

141–184

 

Small Cell (n = 8)

54

50–70

 

52

33–72

 

13

8–16

 

56

42–65

 

215

180–222

 

Gender

  

0.04

  

0.28

  

<0.0001

  

0.002

  

0.0005

Male (n = 125)

99

80–115

 

74

58–95

 

16

7–39

 

27

19–44

 

138

112–171

 

Female (n = 39)

84

70–108

 

83

59–109

 

6

4–13

 

42

27–58

 

168

147–189

 

Age (yrs)

  

0.56

  

0.35

  

0.31

  

0.7

  

0.35

 < 50 (n = 40)

94

72–108

 

72

55–97

 

16

8–39

 

30

22–49

 

154

121–177

 

 > 50 (n = 124)

96

76–114

 

76

59–96

 

11

6–29

 

31

19–48

 

141

114–175

 

Grade

  

0.85

  

0.03

  

0.24

  

0.88

  

0.37

1 (n = 13)

98

84–117

 

96

89–120

 

19

10–138

 

26

18–46

 

141

82–160

 

2 + 3 (n = 135)

97

78–114

 

74

59–95

 

14

6–34

 

29

19–46

 

142

116–172

 

Missing (n = 16)

65

51–89

 

65

35–83

 

11

7–15

 

47

27–58

 

180

130–215

 

T stage

  

0.88

  

0.55

  

0.63

  

0.71

  

0.8

T1/T2 (n = 133)

97

75–112

 

75

58–96

 

13

6–32

 

31

20–48

 

150

115–176

 

T3/T4 (n = 31)

95

77–109

 

76

58–99

 

13

5–34

 

27

18–50

 

142

117–171

 

LN Status

  

0.9

  

0.78

  

0.64

  

0.97

  

0.48

Negative (n = 70)

96

78–111

 

76

60–96

 

13

6–37

 

31

20–46

 

149

117–169

 

Positive (n = 94)

95

75–112

 

74

56–96

 

13

5–31

 

29

20–49

 

145

116–178

 

Stage

  

0.38

  

0.35

  

0.53

  

0.93

  

0.5

I + II (n = 120)

94

75–112

 

74

58–95

 

13

6–32

 

31

20–47

 

151

116–177

 

III + IV (n = 44)

97

79–113

 

82

58–100

 

13

5–34

 

29

20–52

 

141

114–172

 
  1. Immunohistochemical staining were quantified and h-scores were used to compare protein expression levels. Group-levels medians (IQR, interquartile range) for h-score staining intensities are presented. Family-wise alpha significance level is 0.05/8 = 0.006 using the Wilcoxon Rank-Sum test (pairwise) or Kruskal-Wallis test (multiple comparisons). Statistically significant p-values are shown in bold.
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