Table 2 Pharmacokinetic parameters of the oral administration of two alendronate formulations with a fixed dose of 17.5 mg to rabbits (mean ± SD, n = 3).

From: Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates

Formulation

FOSAMAX Tablet

GRDDF tablet (H20-1)

Tmax (h)

0.5

0.83 ± 0.29

Cmax (ng/ml)

188.05 ± 26.51

104.83 ± 17.32

Ke (h−1)

0.09 ± 0.02

0.04 ± 0.01

T1/2 (h)

8.15 ± 1.89

15.50 ± 1.47

AUC0-∞(h · ng/ml)

732.99 ± 144.72

2518.91 ± 272.30

Frel (%)

100%

323.64 ± 1.88

  1. GRDDF, gastroretentive drug dosage form; Tmax, time to the maximum concentration; Cmax, maximum concentration; Ke, terminal elimination rate constant; T1/2, half-life; AUC0-∞, area under the concentration-time curve from 0 to infinity; Frel, relative bioavailability.
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