Table 1 Clinical characteristics of the study population according to respiratory management/surfactant administration.
From: Less invasive surfactant administration and complications of preterm birth
Clinical characteristics | No surfactant | LISA | Surfactant ETT | p | all |
|---|---|---|---|---|---|
Number of infants | 1214 | 2624 | 3695 | 7533 | |
Gestational age (weeks), mean (SD) | 27.4 (1.4) | 26.8 (1.5) | 26.2 (1.6) | <0.001* | 26.6 (1.6) |
Birth weight (g), mean (SD) | 984 (234) | 885 (290) | 814 (244) | <0.001* | 866 (266) |
Mode of birth (%) | <0.001 | ||||
Spontaneous delivery | 13.8 | 8.7 | 11.5 | 10.9 | |
Caesarean section, elective | 76.1 | 81.0 | 72.8 | 76.2 | |
Caesarean section, emergency | 10.0 | 10.3 | 15.6 | 12.9 | |
Cause of preterm birth (%) | |||||
Preterm labour | 47.1 | 40.1 | 42.6 | 0.049 | 42.5 |
Amniotic infection syndrome | 33.7 | 29.2 | 28.8 | 0.7 | 29.8 |
Pathological Doppler/Growth restriction | 11.9 | 17.5 | 15.7 | 0.05 | 15.7 |
Pathological CTG | 18.0 | 17.9 | 18.9 | 0.3 | 18.4 |
Pre-eclampsia | 4.3 | 7.1 | 5.5 | 0.008 | 5.8 |
HELLP syndrome | 4.6 | 8.4 | 7.4 | 0.12 | 7.3 |
Placental abruption | 7.7 | 7.4 | 9.9 | <0.001 | 8.7 |
Apgar scores 5 min/10 min, mean (SD) | 8(1)/9(1) | 8(1)/9(1) | 7(2)/8(1) | <0.001* | 7(2)/8(1) |
Umbilical artery pH, mean (SD) | 7.33 (0.09) | 7.32 (0.09) | 7.31 (0.11) | <0.001* | 7.32 (0.1) |
SGA (< 10th percentile, %) | 6.4 | 11.6 | 15.5 | <0.001* | 12.6 |
Female gender (%) | 50.5 | 46.0 | 45.2 | 0.5 | 46.3 |
Multiple birth (%) | 28.7 | 33.4 | 30.9 | 0.04 | 31.4 |
Inborn (%) | 96.8 | 98.4 | 95.2 | <0.001 | 96.6 |
Antenatal steroids administered (%) | 93.8 | 93.4 | 87.9 | <0.001 | 90.8 |
German maternal background (%) | 68.8 | 72.3 | 73.8 | 0.2 | 72.5 |
Peak FiO2 in first 12h (%) | <0.001 | ||||
21–39% | 81.9 | 51.7 | 40.3 | 51.0 | |
40–59% | 14.0 | 29.1 | 27.3 | 25.8 | |
60–100% | 4.1 | 19.2 | 32.4 | 23.2 | |
Drug treatment of PDA (%) | 20.1 | 47.0 | 46.7 | 0.8 | 42.5 |
Indomethacin | 7.6 | 18.4 | 19.3 | 0.4 | 17.1 |
Ibuprofen | 14.5 | 28.9 | 33.3 | <0.001 | 28.7 |
Postnatal steroids (%) | 6.8 | 17.9 | 33.6 | <0.001 | 23.9 |
Hydrocortisone | 4.9 | 13.4 | 25.7 | 18.1 | |
Dexamethasone | 1.4 | 3.9 | 11.7 | 7.3 | |
Prednisolone | 2.0 | 4.0 | 5.6 | 4.5 | |
