Figure 3

State-dependence of riluzole in comparison with 122 SCI compounds. Data are from Supplement #3 of¹⁵; excluding Nav1.8-selective compounds. Inactivated affinities are plotted against resting affinities. We collected 194 individual data pairs of 122 compounds from 73 publications. Data were calculated from inhibition at different holding potentials, as described in⁴⁰; corrected and standardized, as described in¹⁵. Data for riluzole are shown in red: ♦⁴¹, ◊⁴², ●⁶, o:this study. The black dotted line is the linear regression line, with equation and correlation coefficient (R²). The average state-dependence, calculated from the y intercept of the linear regression line was 24.8-fold. Red dashed lines indicate K_r = K_i; K_r = 10*K_i; and K_r = 100*K_i. The state-dependence of riluzole was above 100-fold in all studies.