Table 2 IC50 values of well-known and new compounds against hPARP1, PdPARP and HaPARP.
Compound | hPARP1 | CdPARP | HaPARP | |
|---|---|---|---|---|
Literature IC50 (nM) | IC50 (nM) | IC50 (µM) | IC50 (µM) | |
Rucaparib | 1.456 | 12.1 ± 1.7 | 5.3 ± 0.7 | 7.2 ± 0.7 |
ABT-888 | 5.257 | 21.0 ± 1.9 | >50 | >50 |
PJ-34 | 2058 | 34.5 ± 3.1 | 32.4 ± 9.8 | 50.4 ± 6.4 |
EB-47 | 4547 | 37.2 ± 4.9 | 0.86 ± 0.07 | 1.0 ± 0.1 |
DPQ | 4059 | 73.8 ± 8.2 | 25.3 ± 7.1 | >50 |
7655698 | — | 81.2 ± 21.3 | — | — |
7650649 | — | 136.1 ± 41.1 | — | — |
7651361 | — | 168.2 ± 44.1 | — | — |
7642078 | — | 181.9 ± 21.4 | — | — |
4-amino 1.8-naphthalimide | 18060 | 247.6 ± 35.9 | — | — |
7669941 | — | 308.4 ± 21.3 | — | — |
7670490 | — | 403.7 ± 53.4 | — | — |
7650155 | — | 458.9 ± 74.7 | — | — |
7660328 | — | 481.3 ± 30.1 | — | — |
TIQ-A | 45061 | 596.3 ± 31.4 | 15.7 ± 4.1 | 7.9 ± 1.7 |
9019116 | — | 676.8 ± 32.7 | — | — |
XAV-939 | 220062 | 726.2 ± 156.1 | >50 | >50 |
