Figure 5 | Scientific Reports

Figure 5

From: Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Figure 5

Translation inhibitors repressed IL-12 and enhanced the activation of B cells in LL2 tumor models. (A) Representative FACS plots of activated B and T cells in the spleens of KrasG12D- expressing LL2 tumor-bearing mice treated with HHT or narciclasine. (B) The average percentage of B220+ CD80+ B cells. (C) The average percentage of B220+ CD86+ B cells. (D) The average percentage of B220+ CD69+ B cells. (E) The average percentage of CD4+ CD69+ T cells. The bar graph represents the average ± SEM (n = 3 mice per group). (F) IL-12 expression levels of splenocytes isolated from KRASG12D-expressing tumor-bearing mice were measured using an ELISA. Mice were treated with HHT or narciclasine. The columns and bars represent mean values ± SEM (n = 2 in NAR group). *p < 0.05, ***p < 0.001. ns, no statistical difference.

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