Figure 3 | Scientific Reports

Figure 3

From: Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

Figure 3

(A) Identification of important features including fecal bacterial taxa and plasma metabolites that correlate with lowest% weight gain. Detailed association data for samples (n = 4) were shown for several features’ association against (B) weight gain and Akkermansia. (C) Correlation between the abundance of fecal Akkermansia, Anaerotruncus and blood glucuronic acid levels, liver weight and percent weight change. Two-tailed pairwise t-tests were performed to identify correlation between indicated factors, metabolites or bacteria level. *P < 0.05, **P < 0.01, ***P < 0.001. (D) The levels of Akkermansia and glucuronic acid following each treatment. Statistical significance was established at α = 0.05. One-way Anova with a Dunn’s correction were used to identify treatments that were significantly different from Veh. *P < 0.05, **P < 0.01, ***P < 0.001.

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