Figure 3

Correlation of IgG + memory B cells cross-reactivity and sera stem binding. (A) Frequencies of HA-specific memory B cell populations in three sera stem-binding groups: negative for stem antibodies, reactive to one stem probe only, and cross-reactive sera which binds 4/5 stem probs. Error bars (red) correspond to standard mean plus SD. Groups were compared using unpaired t-test. (B) Correlation between frequency of cross-reactive B cells and relative sera binding (fold difference) to WT and Δstem probes.