Figure 2

Pearson correlation plots for female Alzheimer’s disease MMSE and ADAS cognitive scores and expression levels (2^−Δct) of SIRT1, miR-132 and miR-212 in their LCLs. (a–c) Pearson correlation plot for MMSE scores and expression levels of (a) SIRT1 (N = 21*), (b) miR-132 (N = 22) and (c) miR-212 (N = 22). (d) Lack of correlation for ADAS scores and SIRT1 expression levels (N = 21*). (e,f) Negative Pearson correlation plots for ADAS scores and expression levels of (e) miR -132 (N = 22) and (f) miR -212 (N = 22). ADAS and MMSE scores were recorded at time of blood withdrawal for LCL generation. Note the negative correlation of SIRT1 expression with MMSE but not with ADAS; the negative MMSE correlation agrees with the positive MMSE correlations for miR-132 and miR-212, two miRNAs known to target SIRT1 (see Discussion). ADAS, Alzheimer’s Disease Assessment Scale; MMSE, Mini-Mental State Examination. *A single outlier LCL was removed from the correlation analysis of ADAS and MMSE scores with SIRT1.