Figure 3

Expression levels of miR-132 (a,c) and miR-212 (b,d) in postmortem olfactory bulb (a,b) and hippocampus (c,d) tissues from sporadic Alzheimer’s disease patients and age-matched non-demented controls and their correlations with MMSE scores. Expression levels (2^−Δct) were determined in postmortem tissue RNA preparations from Alzheimer’s disease patients (N = 14) and age matched non-demented controls (N = 20). See Methods for tissue collection and storage, RNA extractions, and real-time PCR experiments. Bars represent the miR expression averages. Fold-difference (FD) values are shown between cohorts along with P values (Mann-Whitney U test). (e–g) Pearson correlation between AD patients MMSE scores and their postmortem expression levels of (e) olfactory bulb SIRT1, (f) hippocampal miR-132 and (g) hippocampal miR-212.