Figure 4
From: Further evidence for “gain-of-function” mechanism of DFNA5 related hearing loss
Reverse transcriptase PCR analysis of the splice-site variation. (A) Gel electrophoresis of cDNA products. The top band (509 bp) indicates the presence of the wildtype DFNA5 exon8, the bottom band (316 bp) represents the the exclusion of exon8. (B) cDNA sequence chromatograms showing the skipping of exon8 in affected patients (upper panel) compared with the wild type controls (lower panel).
