Table 1 Association analysis of the TNFSF13B BAFF-var in three independent RA cohorts and meta-analysis.

From: Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

Subgroup (N)

Genotype (N)

MAF (%)

Allele test

A|A

A|GCTGT

GCTGT|GCTGT

P-value

OR [95% CI]a

Spain

Controls (3,200)b

10

249

2941

4.20

  

RA (4,429)

11

424

3994

5.03

0.015

1.21 [1.03–1.41]

Netherlands

Controls (733)

0

28

705

1.91

  

RA (890)

0

49

841

2.75

0.115

1.47 [0.91–2.36]

Germany

Controls (470)b

0

19

451

2.02

  

RA (899)

3

44

852

2.78

0.228

1.39 [0.81–2.36]

Meta-analysis c

Controls (4,403)

RA (6,218)

    

0.002

1.24 [1.10–1.38]

  1. Abbreviations: N: Number of individuals; MAF: Minor Allele Frequency; OR: Odds Ratio; CI: Confidence Interval.
  2. aOR for the minor allele.
  3. bHealthy controls were used as reference for RA and SLE patients in Spanish and German subgroups.
  4. cHeterogeneity q value = 0.64, I2 = 0.
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