Figure 4 | Scientific Reports

Figure 4

From: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors

Figure 4

Docking poses of SAA (green), SAB (purple) and SAC (yellow) at the P2Y12 receptor. (a) Comparison of the docking poses of SAA, SAB and SAC with co-crystalized antagonist AZD1283 (magenta) and agonist 2MeSADP (blue) in P2Y12 receptor show that SAA, SAB and SAC can superimpose with the co-crystalized antagonist but not the agonist. (b–d) SAA, SAB and SAC bind the P2Y12 receptor in a similar pose and show good interactions with residues lining the pocket. Light blue solid lines and magenta dashed lines represent hydrogen bonds and π-π/cation-π interactions, respectively.

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