Figure 4
From: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand
(A) G4 ligand activity on HCV replication. Serial dilutions of PhenDC3 (◊) or DMSO (□) were added on Huh7 cells which were then infected with LMTV-GLuc virus. The GLuc activity was measured after 48 hours of culture. The DMSO control corresponds to the DMSO percentage contained in each PhenDC3 concentration. (B) Cytotoxicity analysis of the ligand. Serial dilutions of PhenDC3 (◊) or DMSO (□) were added on Huh7 cells and analyse of cell viability was performed as described in Material and Methods. (n = 2 independent experiments in duplicate/error bars, mean ± SEM).
