Table 2 ly101-4B treated cells.

From: E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

Pathway ID

Downregulated biological process

Observed genes

FDR

GO.0000278

mitotic cell cycle

73

1.46e-59

GO.0007049

cell cycle

80

4.09e-54

GO.0022402

cell cycle process

72

1.01e-51

GO.1903047

mitotic cell cycle process

64

8.23e-51

GO.0006259

DNA metabolic process

54

3.38e-39

GO.0051276

chromosome organization

57

1.03e-37

GO.0051301

cell division

41

3.16e-30

GO.0044770

cell cycle phase transition

36

4.36e-30

GO.0022616

DNA strand elongation

19

1.92e-29

GO.0006260

DNA replication

30

4.43e-28

GO.0006271

DNA strand elongation involved in DNA replication

18

6.24e-28

GO.0007067

mitotic nuclear division

35

7.08e-28

GO.0044772

mitotic cell cycle phase transition

34

8.98e-28

GO.0006281

DNA repair

36

4.7e-26

GO.0006996

organelle organization

75

4.7e-26

GO.0000280

nuclear division

36

6.25e-26

GO.0006974

cellular response to DNA damage stimulus

42

1.52e-25

GO.0090304

nucleic acid metabolic process

80

1.77e-20

GO.0006310

DNA recombination

24

2.16e-20

GO.1902589

single-organism organelle organization

56

2.2e-19

GO.0006261

DNA-dependent DNA replication

18

4.59e-19

GO.0033554

cellular response to stress

51

5.4e-19

GO.0006139

nucleobase-containing compound metabolic process

82

6.98e-19

GO.0046483

heterocycle metabolic process

83

1.97e-18

GO.0000819

sister chromatid segregation

17

5.17e-18

GO.1901360

organic cyclic compound metabolic process

84

8.65e-18

GO.0071840

cellular component organization or biogenesis

83

1.18e-17

GO.0051726

regulation of cell cycle

39

1.19e-17

GO.0016043

cellular component organization

81

5.1e-17

GO.0000070

mitotic sister chromatid segregation

15

1.17e-15

GO.0034641

cellular nitrogen compound metabolic process

83

1.2e-15

GO.0007059

chromosome segregation

20

1.58e-15

GO.0033260

nuclear DNA replication

11

3.39e-15

GO.0098813

nuclear chromosome segregation

17

4.42e-15

GO.0000082

G1/S transition of mitotic cell cycle

19

6.44e-15