Table 1 Effects of HGF on RNA levels of genes increased in repair SCs.

From: Hepatocyte Growth Factor (HGF) Promotes Peripheral Nerve Regeneration by Activating Repair Schwann Cells

Functions

 

Fold increase*

STD

P-value

Transcription factors

Egr1

239.701

48.998

0.014

c-Jun

0.872

0.068

1.000

c-Fos

3.143

0.246

0.002

JunB

3.827

0.244

0.001

Sox10

1.091

0.048

0.600

HIF1a

1.632

0.104

0.011

Notch1

1.445

0.323

0.009

Growth factors

VEGFa

1.202

0.046

0.001

NGF

1.055

0.191

0.724

GDNF

4.118

0.077

0.001

Inflammatory proteins

TNFa

3.003

0.012

0.010

LIF

7.662

0.066

0.004

CCL2/MCP-1

1.266

0.230

0.031

IL1b

1.682

0.099

0.001

IL-6

2.041

0.368

0.063

  1. Primary SCs were treated with 25 ng/ml of HGF protein for 1 hr. Total RNAs were isolated from SCs and analyzed by quantitative RT-PCR. *Fold increase after HGF treatment relative to no treatment. Values represent the mean ± S.E.M. of three independent experiments.
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