Table 3 Fetal growth conditioned on genetic risk.

From: Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation

 

Adjusted

GA2 × GRS

GA2 × BMI

GA2 × Sex

β

%-points·d−1·allele1

P

β

%-points·d−1·m2·kg−1

P

β

%-points·d−1

P

Weight (incl. birth weight)

No

5.71·10−5

(7.21·10−6; 1.07·10−4)

1.42·10−2

(1.44·10−3; 2.1·10−2)

0.025

      

Yes

4.46·10−8 (2.16·10−8; 6.98·10−8)

8.92·10−6 (4.32·10−6; 1.40·10−5)

2.0·10−4

4.1·10−8 (1.87·10−8; 6.24·10−8)

8.2·10−6 (3.74·10−6; 1.25·10−5)

3.3·10−4

−4.99·10−7

(−7.13·10−7; −2.85·10−7)

−9.98·10−5

(−1.43·10−4; −5.7·10−5)

4.7·10−6

Weight (excl. birth weight)

No

3.35·10−5 (1.34·10−6; 6.57·10−5)

6.7·10−3 (2.68·10−4; 1.3·10−2)

0.041

      

Yes

3.74·10−8 (8.21·10−9; 6.65·10−8)

7.78·10−6 (1.64·10−6; 1.33·10−5)

0.012

4.21·10−8 (1.58·10−8; 6.65·10−8)

8.42·10−6 (3.16·10−6; 1.33·10−5)

0.0017

−4.53·10−7

(−7.1·10−7; −1.95·10−7)

−9.06·10−5

(−1.4·10−4; −3.9·10−5)

5.9·10−4

Occipitofrontal diameter

No

4.13·10−7

(−7.14·10−7; 1.54·10−6)

8.3·10−5

(−1.43·10−4; 3.08·10−4)

0.470

      

Yes

4.29·10−9 (−7.09·10−9; 1.57·10−8)

8.58·10−7 (−1.42·10−6; 3.14·10−6)

0.460

1.20·10−8 (1.69·10−9; 2.22·10−8)

2.4·10−6 (3.38·10−7; 4.44·10−6)

0.022

−3.27·10−7

(−4.27·10−7; −2.26·10−7)

−6.54·10−5

(−8.54·10−5; −4.52·10−5)

2.2·10−10

Abdominal circumference

No

4.49·10−6 (1.11·10−6; 7.88·10−6)

8.9·10−4 (2.22·10−4; 15.76·10−4)

0.009

      

Yes

1.61·10−8 (3.01·10−9; 2.91·10−8)

3.22·10−6 (6.02·10−7; 5.82·10−6)

0.016

1.3·10−8 (1.41·10−9; 2.50·10−8)

2.6·10−6 (2.82·10−7; 5·10−6)

0.028

−1.69·10−7 (−2.84·10−7; −5.29·10−8)

−5.07·10−5 (−5.68·10−5; −1.06·10−5)

0.0043

Femur length

No

4.23·10−7 (−1.92·10−7; 1.04·10−6)

8.46·10−5 (−3.84·10−6; 2.08·10−6)

0.178

      

Yes

4.23·10−7 (−1.92·10−7; 1.04·10−6)

8.46·10−5

(−3.84·10−5; 2.08·10−4)

0.178

8.8·10−7 (3.31·10−7; 1.44·10−6)

1.7·10−4 (6.6·10−5; 2.9·10−6)

0.0018

1.97·10−8 (−3.48·10−6; 7.42·10−6)

3.94·10−6

(−6.96·10−4; 1.5·10−3)

0.480

Biparietal diameter

No

5.33·10−7 (−4.55·10−7; 1.52·10−6)

1.66·10−4 (−9.1·10−5; 3.04·10−4)

0.290

      

Yes

5.95·10−9 (−6.02·10−9; 1.79·10−8)

1.19·10−6 (−1.20·10−6; 3.58·10−6)

0.330

9.64·10−9 (−1.15·10−9; 2.04·10−8)

1.93·10−6 (−2.3·10−7; 4.08·10−6)

0.080

−3.14·10−7 (−4.2·10−7; −2.08·10−7)

−6.28·10−5 (−8.4·10−5; −4.15·10−5)

6.8·10−9

  1. Data is presented as raw parameter estimates (β) and estimates transformed to the original scale with respective 95% confidence intervals and corresponding P values. Fetal growth conditioned on genetic birth weight risk score (GRS) with or without co-conditioning on maternal pre-pregnancy body mass index (BMI) and fetal sex was modelled using linear mixed regression. GA2 × GRS represents the additive per allele effect of the GRS on change in daily proportional weight gain per day. GA2 × BMI represent the additive effect of a one unit (kg·m2) increment in BMI on change in daily proportional weight gain per day. GA2 × Sex represent the additive effect of female fetal sex on change in daily proportional weight gain per day.
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