Table 4 Association of genetic variants with adult onset disease in the UK biobank.

From: Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation

Variant

EA

Type 2 diabetes

(n = 19.630)

P value

Hypertension

(n = 77,533)

P value

BMI

(n = 490,000)

P value

β ± SE

β ± SE

β ± SE

rs7964361

C

−0.000 ± 0.001

0.935

0.001 ± 0.001

0.554

0.030 ± 0.017

0.067

rs61154119

T

−0.001 ± 0.001

0.129

−0.000 ± 0.001

0.827

0.009 ± 0.013

0.473

rs1374204

T

0.000 ± 0.001

0.412

−0.001 ± 0.001

0.198

0.020 ± 0.01

0.060

rs72851023

T

−0.001 ± 0.001

0.060

−0.003 ± 0.002

0.091

0.051 ± 0.018

0.004

rs700059

G

−0.002 ± 0.001

0.0007

−0.002 ± 0.001

0.034

−0.030 ± 0.014

0.026

rs10830963

G

0.003 ± 0.001

6.37E-11

−0.000 ± 0.001

0.643

0.028 ± 0.010

0.008

rs138715366

C

0.002 ± 0.002

0.490

−0-004 ± 0.004

0.366

0.025 ± 0.050

0.613

rs2150052

T

−0.001 ± 0.000

0.206

−0.002 ± 0.001

0.039

−0.005 ± 0.009

0.600

  1. Analyses assessing the effect of genetic variants associated with intrauterine growth in this study and their impact on adult onset type 2 diabetes, hypertension and BMI in the UK biobank of 19,630–490,000 individuals. Occurrence of Type 2 diabetes and hypertension are based on ICD-10 codes. BMI is measured at inclusion in the UK biobank. EA: Effect allele. P values are calculated by linear regression or logistic regression models.
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