Figure 4 | Scientific Reports

Figure 4

From: Basal interferon signaling and therapeutic use of interferons in controlling rotavirus infection in human intestinal cells and organoids

Figure 4

Exogenous treatment of type I, II and III IFNs inhibits RV SA11 infection. Antiviral activity of IFNα, IFNβ, IFNγ, IFNλ1, IFNλ2 and IFNλ3 treatment against RV SA11 infection on (A) Caco2 cells (n = 2–3 independent experiments with each of 3–4 replicates) and (C) organoids (n = 3 independent experiments with each of 2–3 replicates) at 48 hours after infection. Data were presented as means ± SEM., *P < 0.05; **P < 0.01; ***P < 0.001. (B) A representative picture of the morphology of human small intestinal organoid at day 4 post embedding in Matrigel. The organoid used in this experiment was derived from one individual (P1).

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