Table 3 Comparison between the IgG glycan markers19 to the plasma glycan markers found in this work.

From: Plasma N-glycans in colorectal cancer risk

Predominant Glycan

Plasma CRC change

This work’s Peak

IgG change CRC19

IgG Peak from19

Likely plasma protein(s)*

Amino acid

Protein plasma concentration (% of total)^

FA2

Increased

GP01

Increased

GP4

IgG

Asn297, Asn322 (IgG3)

40.4%

FA2[6]G1

Decreased

GP04

Decreased

GP08

IgG

Asn297, Asn322 (IgG3)

40.4%

FA2[3]G1

Decreased

GP05

Decreased

GP09

IgG

Asn297, Asn322 (IgG3)

40.4%

A2[3]G1S[3]1

Decreased

GP08

NF

NF

?

?

?

A2G2

Decreased

GP08

Decreased

GP12

IgG, Apo

Asn297 (IgG), Asn322 (IgG3)

40.4% (IgG), 0.5% (Apo)

FA2G2

Decreased

GP11

Decreased

GP14

IgG

Asn297 (IgG), Asn322 (IgG3)

40.4%

FA2BG2

Decreased

GP12

Decreased

GP15

IgG

Asn297 (IgG), Asn322 (IgG3)

40.4%

FA2G2S1

Decreased

GP18

Decreased

GP18

IgG, IgA, IgE, IgD, IgM, A2M

Asn297 (IgG), Asn322 (IgG3), Asn340(IgA), Asn46(IgM), Asn209(IgM), Asn272(IgM)

40.4% (IgG), 9.0% (IgA), 0.1% (IgD), 5.0% (IgM)

A2F1G2S1

Decreased

GP20

NF

NF

Apo D, Haptoglobin

Asn98 (Apo D), Asn184(Hapto), Asn207 (Hapto), Asn241 (Hapto)

0.3% (ApoD), 4.5% (Hapto)

A2BG2S2

Increased

GP24

Decreased

GP22

IgG

Asn297 (IgG), Asn322 (IgG3)

40.4%

FA3G3S1

Increased

GP24

NF

NF

?

?

?

FA3BG3S1

Increased

GP24

NF

NF

?

?

?

A3G3S2

Increased

GP27

NF

NF

B2, Apo D, Hapto, Sero

Asn65 (Apo D), Asn162 (B2), Asn193 (B2), Asn184 (Hapto), Asn211 (Hapto), Asn241 (Hapto), Asn432 (Sero), Asn630 (Sero)

0.7% (B2),

0.3% (Apo D),

4.5% (Hapto),

8.5% (Sero)

A3BG3S2

Increased

GP27

NF

NF

?

?

?

FA3G3S3

Increased

GP32

NF

NF

?

?

?

A4G4S3

Increased

GP37

NF

NF

AGP

Asn72, Asn93, Asn103

2.6% (AGP)

A4F1G3S3

Increased

GP38

NF

NF

AGP

Asn93

2.6% (AGP)

A4G4S4

Increased

GP42

NF

NF

AGP, Apo D, CP

Asn65 (Apo D), Asn762 (CP)

2.6% (AGP), 1.2% (CP),

0.3% (ApoD)

A4F1G4S4

Increased

GP42

NF

NF

AGP, CP

Asn762 (CP)

2.6% (AGP), 1.2% (CP)

  1. *The possible plasma protein and amino acid site involved for each glycan derived from21 and the previous IgG CRC study19, in bold the highest concentration. NF: not found in the IgG profile. For simplicity we did not separate by linkage isomers since all followed the same trend (e.g. A4G4S[3,3,3,3]4 and A4G4S[3,3,3,6]4 both increased in plasma CRC). Abbreviated proteins (UniProt ID)- AGP: Alpha-1-acid glycoprotein (P02763; P19652), A2M: Alpha-2-macroglobulin (P01023), Apo: Apolipoprotein B-100 (P04114), Apo D: Apolipoprotein D (P05090), CP: Ceruloplasmin (P00450), Hapto: Haptoglobin (P00738), B2: Beta-2-glycoprotein I (P02749). Sero: Serotransferrin (P02787). IgA: Immunoglobulin A (P01876, P01877), IgD: Immunoglobulin D (P01880), IgE: Immunoglobulin E (P01854), IgG: Immunoglobulin G (P01857, P01859, P01860, P01861), IgM: Immunoglobulin M (P01876, P01877), ?: unknown. ^Approx. derived from21.
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