Figure 5
From: Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
RAS/RBD/CRD ternary complex models based on CG simulations with no pre-defined RAS/CRD association. (a) Snapshots showing the Membrane-adjacent/GH5 (left) and membrane-adjacent/GH3 (right) orientations observed in the CG simulations. The CRD, RBD and RAS are colored as in Fig. 4, but with helices 3, 4, and 5 of the RAS colored red, green, and orange, respectively, in order to show their disposition relative to the membrane surface. (b) Residue contacts between RAS/CRD (top) and between RBD/CRD (bottom) for the Membrane-adjacent/GH5 orientation are highlighted (see contact maps in Supp. Fig. 18a). (c) Residue contacts between RAS/CRD (top) and between RBD/CRD (bottom) for the Membrane-adjacent/GH3 orientation are highlighted (see contact maps in Supp. Fig. 18b).
