Table 1 Clinical and pathological variables as predictors of disease-specific survival (DSS) in NSCLC patients (univariate analyses; log-rank test; N = 553, 180 and 373, respectively).
Overall cohort | Female patients | Male patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
N(%) | 5 year DSS (%) | Median DSS (mo) | p | N(%) | 5 year DSS (%) | Median DSS (mo) | p | N(%) | 5 year DSS (%) | Median DSS(mo) | p | |
Age | 0.656 | 0.637 | 0.827 | |||||||||
≤65 | 234 (42.3) | 58 | 127 | 77 (42.8) | 62 | 190 | 157 (42.1) | 56 | 98 | |||
>65 | 319 (57.7) | 58 | NR | 103 (57.2) | 65 | NR | 216 (57.9) | 44 | 88 | |||
Sex | 0.025 | |||||||||||
Female | 180 (32.5) | 64 | 190 | |||||||||
Male | 373 (67.5) | 55 | 91 | |||||||||
ECOG perf. status | 0.009 | 0.400 | 0.020 | |||||||||
0 | 324 (58.6) | 63 | 235 | 112 (62.2) | 67 | NR | 212 (56.8) | 60 | 235 | |||
1 | 191 (34.5) | 52 | 71 | 56 (31.1) | 60 | 127 | 135 (36.2) | 48 | 51 | |||
2 | 38 (6.9) | 52 | NR | 12 (6.7) | 55 | NR | 26 (7.0) | 50 | NR | |||
Smoking | 0.069 | 0.732 | 0.060 | |||||||||
Never | 21 (3.8) | 50 | 21 | 11 (6.1) | 64 | 189 | 10 (2.7) | 33 | 18 | |||
Present | 350 (63.3) | 62 | 235 | 115 (63.9) | 67 | NR | 235 (63.0) | 59 | 235 | |||
Previous | 182 (32.9) | 52 | 84 | 54 (30.0) | 58 | NR | 128 (34.3) | 49 | 57 | |||
Weightloss | 0.971 | 0.603 | 0.637 | |||||||||
<10% | 498 (90.1) | 58 | 190 | 163 (90.6) | 63 | 190 | 335 (89.8) | 56 | 91 | |||
≥10% | 55 (9.9) | 59 | NR | 17 (9.4) | 68 | NR | 38 (10.2) | 54 | 98 | |||
Surgical procedure | <0.001 | 0.024 | <0.001 | |||||||||
Wedge/Lobectomy | 411 (74.3) | 64 | 235 | 148 (82.2) | 68 | 190 | 263 (70.5) | 61 | 235 | |||
Pulmonectomy | 142 (25.7) | 42 | 30 | 32 (17.8) | 42 | 37 | 110 (29.5) | 42 | 29 | |||
Margins | 0.105 | 0.088 | 0.431 | |||||||||
Free | 506 (91.5) | 59 | 190 | 166 (92.2) | 65 | 190 | 340 (91.2) | 56 | 98 | |||
Not free | 47 (8.5) | 47 | 57 | 14 (7.8) | 51 | 64 | 33 (8.8) | 45 | 47 | |||
Tstage | <0.001 | 0.009 | <0.001 | |||||||||
1a | 14 (2.5) | 93 | NR | 5 (2.8) | 100 | NR | 9 (2.4) | 89 | NR | |||
1b | 71 (12.8) | 79 | NR | 30 (16.7) | 82 | NR | 41 (11.0) | 77 | NR | |||
1c | 95 (17.2) | 64 | 190 | 33 (18.3) | 66 | NR | 62 (16.6) | 63 | 235 | |||
2a | 135 (24.4) | 57 | 88 | 35 (19.4) | 65 | NR | 100 (26.8) | 54 | 83 | |||
2b | 73 (13.2) | 48 | 47 | 28 (15.6) | 60 | NR | 45 (12.1) | 40 | 40 | |||
3 | 104 (18.8) | 56 | NR | 36 (20.0) | 60 | NR | 68 (18.2) | 54 | 98 | |||
4 | 61 (11.1) | 31 | 21 | 13 (7.2) | 23 | NR | 48 (12.9) | 36 | 19 | |||
Nstage | <0.001 | <0.001 | <0.001 | |||||||||
0 | 379 (68.5) | 70 | 235 | 132 (73.3) | 74 | NR | 247 (66.2) | 67 | 235 | |||
1 | 118 (21.3) | 36 | 35 | 23 (12.8) | 42 | 47 | 95 (25.5) | 35 | 27 | |||
2 | 56 (10.2) | 23 | 21 | 25 (13.9) | 30 | 35 | 31 (8.3) | 16 | 15 | |||
Pathological stage | <0.001 | <0.001 | <0.001 | |||||||||
I | 232 (42.0) | 74 | 235 | 78 (43.3) | 81 | NR | 154 (41.3) | 70 | 235 | |||
II | 185 (33.4) | 59 | 114 | 61 (33.9) | 66 | NR | 124 (33.2) | 56 | 91 | |||
IIIA + B | 136 (24.6) | 28 | 21 | 41(22.8) | 29 | 36 | 95 (25.5) | 27 | 17 | |||
Histology | 0.241 | 0.431 | 0.125 | |||||||||
SQCC | 307 (55.5) | 64 | 235 | 77 (42.8) | 71 | NR | 230 (61.7) | 61 | 235 | |||
ADC | 239 (43.2) | 52 | 73 | 100 (55.6) | 59 | 190 | 139 (37.3) | 46 | 57 | |||
Othera | 7 (1.3) | 67 | NR | 3 (1.6) | 50 | 11 | 4 (1.0) | 75 | NR | |||
Vascular infiltration | <0.001 | 0.040 | <0.001 | |||||||||
No | 453 (82.0) | 62 | 235 | 136 (75.6) | 68 | 190 | 317 (85.0) | 60 | 235 | |||
Yes | 97 (17.5) | 38 | 35 | 42 (23.3) | 49 | 47 | 55 (14.7) | 25 | 22 | |||
Missing | (0.5) | 2 (1.1) | 1 (0.3) | |||||||||
