Table 3 Results of Cox regression analysis summarizing significant independent prognostic factors for disease-specific survival (DSS) in primary tumors (PT) in the overall cohort and stratified by gender (N = 553, 180 and 373, respectively).

From: A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer

 

Overall cohort

p

Female patients

p

Male patients

p

HR (95% CI)

HR (95% CI)

HR (95% CI)

Pstage

 

<0.001

 

<0.001

 

<0.001

I

1 (ref)

 

1 (ref)

 

1 (ref)

 

II

1.47 (1.03–2.09)

0.033

1.80 (0.92–3.55)

0.088

1.45 (0.96–2.18)

0.075

IIIA + IIIB

3.82 (2.69–5.44)

<0.001

5.02 (2.64–9.55)

<0.001

3.36 (2.28–5.06)

<0.001

Vascular infiltration

 

0.001

 

0.049

 

0.001

No versus Yes

1.82 (1.30–2.57)

 

1.75 (1.00–3.06)

 

2.10 (1.37–3.22)

 

Sex

 

0.010

NE

 

NE

 

Female versus Male

1.50 (1.10–2.04)

     

ECOG perf. status

 

0.028

NE

  

0.050

0

1 (ref)

   

1 (ref)

 

1

1.45 (1.09–1.93)

0.012

  

1.51 (1.08–2.11)

0.017

2

1.57 (0.82–3.03)

0.176

  

1.47 (0.71–3.08)

0.301

Primary tumors

S-miR143

   

0.019

NE

 

Low vs High

NE

 

0.53 (0.31–0.90)

   

S-miR145

NE

    

0.021

Low vs High

    

0.58 (0.37–0.92)

 

S-miR143/S-miR145

 

0.027

NE

  

0.027

Low vs High

0.57 (0.35–0.94)

   

0.50 (0.27–0.92)

 
  1. Abbreviations: S-miR, stromal miR expression. CI, confidence interval. ECOG perf. status, Eastern Cooperative Oncology Group performance status. HR, Hazard ratio. NE, not entered.
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