Figure 4
The extended models are quantitatively in agreement with previous experimental data, in contrast to the original model of Obbink-Huizer et al.29 that cannot predict SF alignment in biaxially constrained high-density collagen gels statically constrained for 3 days and cyclically stretched for additional 3 days. The figures show a comparison of the order parameters of the SF distributions in biaxially constrained collagen gels, as predicted by the two extended computational models (blue for contact guidance, red for steric hindrance) and the original model of Obbink-Huizer et al.29 (green), with low (A,C) and high (B,D) collagen densities. When available in the literature15, previous experimental results were reported by showing the mean order parameter and the standard deviation (black).
