Table 3 Comparison of serum cotinine levels, breath analysis test, FTND levels between the two arms.

From: Impact of nicotine replacement therapy as an adjunct to anti-tuberculosis treatment and behaviour change counselling in newly diagnosed pulmonary tuberculosis patients: an open-label, randomised controlled trial

Test

Counselling+ NRT

Counselling alone

Difference (95% C·I.)

p value

n

Mean ± SD

N

Mean ± SD

Serum cotinine levels (ng/mL)

Baseline

328

97·24 ± 5·3

320

97·52 ± 5·59

0·27 (−0·56, 1·12)

0·510

2nd week

317

86·06 ± 15·5

311

90·60 ± 13·87

4·53 (2·23, 6·84)

0·001

4th week

314

71·87 ± 22·7

305

78·38 ± 18·01

6·54 (3·26, 9·74)

0·001

2nd month

309

57·86 ± 28·1

300

66·63 ± 21·9

8·77 (4·75, 12·79)

0·001

6th month

307

45·87 ± 32·7

297

55·12 ± 27·31

9·25 (4·42, 14·07)

0·002

Total change

 

51·48 ± 33·5

 

43·36 ± 27·09

9·11 (4·23, 13·99)

0·0003

BAT (ppm)

Baseline

387

17·82 ± 6·68

391

17·52 ± 7·13

−0·30 (−1·27, 0·66)

0·540

2nd week

375

14·19 ± 6·12

380

14·24 ± 5·48

0·005 (−0·78, 0·88)

0·900

4th week

371

11·21 ± 4·85

374

11·25 ± 4·37

0·04 (−0·62, 0·71)

0·890

2nd month

368

9·39 ± 3·95

370

10·12 ±  5·62

0·73 (0·029, 1·43)

0·040

6th month

375

7·82 ± 3·29

372

8·51 ± 3·2

0·69 (0·22, 1·15)

0·003

Total change

 

9·8 ± 6·2

 

8·8 ± 6·9

0·94 (0·14, 1·90)

0·053

FTND

Baseline

398

6·85 ± 1·06

397

6·73 ± 1·13

−0·11 (0·27, 0·34)

0·120

2nd week

387

4·49 ± 1·39

390

4·93 ± 1·36

0·44 (0·24, 0·63)

0·001

4th week

384

2·84 ± 1·58

384

3·46 ± 1·5

0·62 (0·40, 0·84)

0·001

2nd month

380

1·58 ± 1·4

380

2·54 ± 1·52

0·96 (0·75, 1·16)

0·001

6th month

375

1·38 ± 1·25

375

2·13 ± 1·34

0·75 (0·56,·93)

0·001

Total change

 

5·45 ± 1·6

 

4·61 ± 1·8

0·83 (0·59, 1·07)

0·001

  1. mITT = modified intention to treat, ATT = Anti-tuberculosis therapy, NRT = nicotine replacement therapy BAT = Breath analysis test, FTND = Fagerstrom Test for Nicotine Dependence, C.I. = confidencce interval.
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