Figure 4 | Scientific Reports

Figure 4

From: Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus

Figure 4

PSTi8 regulate secreation of biomolecule, glycogen storage and hepatic gene expression. Plasma concentrations of (a–c) insulin, (d–f) leptin, (g–i) IL-6, (j–l) MCP1, (p,q) NEFA-C and (m–o) liver glycogen in db/db, HFD, HFrD mice and PSTi8 treated db/db, HFD, HFrD mice. α, db/db, HFD, HFrD mice vs PSTi8 treated db/db, HFD, HFrD mice. (r–t) Effect of PSTi8 treatment on db/db, HFD and HFrD mice for the expression of glucose and lipid metabolic genes, (Pepck, G6pase, Pfk1, Pk, Pparγ, Srebp-1c and Fas) for db/db, (Pepck, G6pase, Pfk1, Pparγ, Srebp-1c, FoxO1 and Fas) for HFD, (Pepck, G6pase, Pfk1, Pk, Pparγ, Pgc1α, Srebp-1c and FoxO1) for HFrD in liver tissue. α, db/db vs db/db + PSTi8, HFD vs HFD + PSTi8, HFrD vs HFrD + PSTi8. *P < 0.05; **P < 0.01; ***P < 0.001. Error bar indicate mean ± s.e.m.

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